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Manfred Kaufmann Selected Research

Polo-Like Kinase 1

8/2010Polo-like kinase 1 as predictive marker and therapeutic target for radiotherapy in rectal cancer.
2/2010Biological impact of freezing Plk1 in its inactive conformation in cancer cells.
2/2009Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21(WAF1/CIP1).
6/2006Down-regulation of Polo-like kinase 1 elevates drug sensitivity of breast cancer cells in vitro and in vivo.
1/2006Tumor inhibition by genomically integrated inducible RNAi-cassettes.
4/2005Conditional inhibition of cancer cell proliferation by tetracycline-responsive, H1 promoter-driven silencing of PLK1.
6/2004Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1.
8/2002Efficient internalization of the polo-box of polo-like kinase 1 fused to an Antennapedia peptide results in inhibition of cancer cell proliferation.

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Manfred Kaufmann Research Topics

Disease

75Breast Neoplasms (Breast Cancer)
11/2014 - 01/2002
57Neoplasms (Cancer)
11/2014 - 01/2002
6Carcinoma (Carcinomatosis)
01/2009 - 05/2002
3Uterine Cervical Neoplasms (Cancer of the Cervix)
12/2008 - 12/2002
3Endometriosis
08/2008 - 10/2007
3Neoplasm Metastasis (Metastasis)
01/2008 - 10/2004
2Neutropenia
03/2013 - 10/2004
2Febrile Neutropenia
03/2013 - 04/2010
2Exanthema (Rash)
01/2013 - 02/2012
2Pathologic Complete Response
05/2012 - 04/2010
2Inflammatory Breast Neoplasms
05/2012 - 01/2010
2Triple Negative Breast Neoplasms
01/2012 - 10/2011
2Alopecia (Baldness)
01/2012 - 10/2004
2Colorectal Neoplasms (Colorectal Cancer)
08/2010 - 12/2006
2Endometrial Neoplasms (Endometrial Cancer)
12/2006 - 06/2006
2Noninfiltrating Intraductal Carcinoma (DCIS)
02/2006 - 03/2005
1Shellfish Poisoning
12/2015
1Ciguatera Poisoning (Ciguatera)
09/2015
1Digestive System Diseases
01/2013
1Birth Weight (Birth Weights)
09/2012
1Melanoma (Melanoma, Malignant)
01/2012
1Testicular Neoplasms (Testicular Cancer)
01/2012
1Inflammation (Inflammations)
10/2011
1Headache (Headaches)
10/2011
1Rectal Neoplasms (Rectal Cancer)
08/2010
1Diarrhea
04/2010
1Cardiotoxicity
04/2010
1Conjunctivitis
04/2010

Drug/Important Bio-Agent (IBA)

15Hormones (Hormone)IBA
10/2013 - 04/2005
13Estrogen ReceptorsIBA
11/2011 - 03/2005
13TamoxifenFDA LinkGeneric
01/2010 - 10/2002
12Proteins (Proteins, Gene)FDA Link
11/2011 - 10/2002
11Doxorubicin (Adriamycin)FDA LinkGeneric
12/2010 - 10/2002
11Docetaxel (Taxotere)FDA Link
04/2010 - 10/2002
10Trastuzumab (Herceptin)FDA Link
11/2014 - 06/2006
10Cyclophosphamide (Cytoxan)FDA LinkGeneric
04/2010 - 10/2002
8Polo-Like Kinase 1IBA
08/2010 - 08/2002
7Small Interfering RNA (siRNA)IBA
12/2008 - 06/2004
6human ERBB2 proteinIBA
10/2013 - 01/2009
6Messenger RNA (mRNA)IBA
08/2011 - 12/2002
5AnthracyclinesIBA
05/2012 - 12/2002
5taxaneIBA
05/2012 - 10/2004
5Capecitabine (Xeloda)FDA Link
01/2012 - 04/2008
5Epirubicin (Ellence)FDA LinkGeneric
04/2010 - 12/2002
5Aromatase InhibitorsIBA
01/2010 - 12/2005
5Progesterone Receptors (Progesterone Receptor)IBA
01/2010 - 03/2005
5Anastrozole (Arimidex)FDA LinkGeneric
01/2010 - 08/2005
4Phenobarbital (Luminal)FDA Link
10/2013 - 12/2007
4Biomarkers (Surrogate Marker)IBA
05/2012 - 01/2008
4Goserelin (Zoladex)FDA Link
10/2011 - 08/2005
4ErbB Receptors (EGF Receptor)IBA
04/2010 - 10/2002
4Phosphotransferases (Kinase)IBA
02/2010 - 05/2002
4SphingolipidsIBA
08/2009 - 11/2008
4Epidermal Growth Factor (EGF)IBA
11/2005 - 05/2002
3Taxoids (Taxanes)IBA
03/2013 - 12/2002
3Paclitaxel (Taxol)FDA LinkGeneric
12/2008 - 12/2002
3Letrozole (Femara)FDA LinkGeneric
03/2007 - 08/2005
3Monoclonal AntibodiesIBA
01/2007 - 04/2003
3Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2006 - 09/2002
2ClaudinsIBA
10/2011 - 08/2008
2ParaffinIBA
09/2011 - 02/2006
2Gonadotropin-Releasing Hormone (GnRH)FDA Link
12/2010 - 08/2005
2Biological ProductsIBA
02/2010 - 02/2007
2Methotrexate (Mexate)FDA LinkGeneric
01/2010 - 11/2007
2Fluorouracil (Carac)FDA LinkGeneric
01/2010 - 11/2007
2EnzymesIBA
08/2009 - 04/2003
2GangliosidesIBA
08/2009 - 11/2008
2plexinIBA
02/2009 - 02/2007
2SteroidsIBA
01/2009 - 02/2006
2Cyclin B1IBA
12/2008 - 07/2004
2Vinorelbine (Navelbine)FDA LinkGeneric
04/2008 - 10/2004
2Pharmaceutical PreparationsIBA
12/2006 - 06/2006
2Antisense OligonucleotidesIBA
06/2006 - 05/2002
2Estrogens (Estrogen)FDA Link
06/2006 - 01/2006
2Tetracycline (Achromycin)FDA LinkGeneric
01/2006 - 04/2005
2Therapeutic UsesIBA
04/2003 - 10/2002
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
12/2015
1Okadaic AcidIBA
12/2015
1CiguatoxinsIBA
09/2015
1Colony-Stimulating Factors (Colony Stimulating Factor)IBA
03/2013
1Lapatinib (GW572016)FDA Link
01/2013
1AntigensIBA
01/2012
1Ibandronic Acid (Boniva)FDA Link
10/2011
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
09/2011
1RNA (Ribonucleic Acid)IBA
09/2011
1Formaldehyde (Formol)FDA Link
09/2011
1lysine(6)-doxorubicin LHRHIBA
12/2010
1LHRH Receptors (Gonadotropin-Releasing Hormone Receptor)IBA
12/2010
1Caspase 3 (Caspase-3)IBA
08/2010

Therapy/Procedure

33Therapeutics
11/2011 - 01/2002
20Neoadjuvant Therapy
10/2013 - 10/2002
17Drug Therapy (Chemotherapy)
10/2013 - 12/2002
4Adjuvant Chemotherapy
01/2013 - 01/2007
4Segmental Mastectomy (Lumpectomy)
07/2012 - 01/2005
3Radiotherapy
08/2010 - 01/2005
2Chemoprevention
10/2011 - 01/2007
2Mastectomy (Mammectomy)
01/2010 - 03/2007
2Aftercare (After-Treatment)
07/2007 - 01/2005
1Palliative Care (Palliative Therapy)
11/2014
1Combined Modality Therapy
08/2010